Mrs. Harrison is about two women and one story. At their 10-year college reunion, Aisha and Holly meet by chance. Is this the first time or has it just been a long time? They can't agree. Aisha is a black, successful playwright; she's on the cover of the alumni magazine. Holly is a white, struggling stand-up comedian; she's here for the free drinks. Aisha's most successful play bears a striking resemblance to a tragic event in Holly's life. Is it a coincidence or is it theft? As a rainstorm interrupts the outdoor reunion, they find themselves trapped inside, together. They both have a story that they've been telling themselves about what happened all those years ago and they're both willing to fight for the truth in the present.