Set in an alternative world where aliens have come to Earth and integrated with society, LaGuardia revolves around a pregnant Nigerian-American doctor, Future Nwafor Chukwuebuka who has just returned to NYC under mysterious conditions, who smuggles an illegal alien plant named 'Letme Live' through customs and security. There, she and Letme become part of a growing population of mostly African and shape-shifting alien immigrants, battling against interrogation, discrimination and travel bans, as they try to make it in a new land.